I'm getting read to put together something that's a cross between a series of podcasts, and a seminar style course. The basic notion is to have a series of podcasts, each followed by Q&A & discussion in a forum or on an email list; with some supporting materials accumluated on a wiki. Wash, rinse repeat.
I'm still looking for the right platform to build on. Haven't decided yet whether to start with WordPress or Drupal, or some podcasting platform, or an LMS like Moodle. Or just cobble things together from piece parts.